Bacterial Infections and the Kidney by Anjali A. Satoskar & Tibor Nadasdy

Author:Anjali A. Satoskar & Tibor Nadasdy
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Fig. 4.14Subendothelial electron dense deposit in a patient with diffuse proliferative glomerulonephritis associated with prosthetic aortic valve Streptococcus viridans infective endocarditis (osmium tetroxide, ×12,000)

Clinicopathologic Correlation

Infectious Agent and Biopsy Findings

Interestingly, although there was no statistical difference between the occurrences of staphylococcal or streptococcal species on blood cultures between pauci-immune cases and those with immune complex deposition in our series, all cases with Bartonella, Coxiella, or Cardiobacterium on culture had immunoglobulin and C3 deposition by immunofluorescence [49]. We did not find significant associations between the bacterial agent on culture and the various light microscopic patterns of glomerulonephritis except that most cases with Bartonella, Coxiella, Cardiobacterium, or Gemella had crescentic glomerulonephritis and 3/4 cases of culture-negative endocarditis patients had crescentic glomerulonephritis. Similarly, Bookman et al. [4] and Liapis (referenced in [23]) presented 4 cases of B. henselae endocarditis-associated necrotizing and crescentic glomerulonephritis which mimicked vasculitis by light microscopy, with C3 staining by immunofluorescence and mesangial and subendothelial deposits by electron microscopy [4, 23].

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